William Bosworth Castle: pioneer of haematological clinical investigation.

نویسندگان

  • Jeffrey M Elrod
  • Anand B Karnad
چکیده

William Bosworth Castle (1897–1990) spent his entire haematological career at the Harvard Medical Unit and Thorndike Memorial Laboratory at Boston City Hospital during the golden age of haematology. Castle’s experiments in solving the puzzle of pernicious anaemia by identifying the intrinsic factor are models of clinical investigation and marked a new era in haematology. Castle’s insatiable curiosity about the mechanisms of disease, his ability to design and conduct simple experiments to test hypotheses, and his ability to attract clinical investigators to the Thorndike Laboratory, and inspire them and make them feel like intellectual equals, fuelled the dramatic output of seminal work on nutritional anaemias, haemolysis, splenic function, haemoglobin physiology and coagulation. Indeed it was Castle’s breadth of scientific achievements in haematology and his leadership of the Thorndike Memorial Laboratory that contributed to the notion that modern haematology was born in Boston but nurtured at the Thorndike Memorial Laboratory.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Gregory Goodwin Pincus (1903-1967)

Gregory Goodwin Pincus [4], one of the original researchers responsible for the development of the first oral contraceptive pill [5], was born in Woodbine, New Jersey, on 19 April 1903 to Russian Jewish parents. In 1924 Pincus received his BS degree from Cornell University [6], and in 1927 he received his MS and PhD from Harvard University [7], having studied under William Ernest Castle [8] and...

متن کامل

Effects of dietary fish oil replacement by vegetable oil on the serum biochemical and haematological parameters of African catfish (Heterobranchus longifilis) fingerlings

The present study aimed to elucidate the impacts of dietary vegetable oil blends as alternative to fish oil on serum biochemical and haematological parameters in Heterobranchus longifilis fingerlings. Fish (4.65 ± 0.23g) were fed diets containing fish oil (FO), palm oil (PO), soybean oil (SO), blend of PO and SO (POSO) over a 12-week period. The experiment was carried out in 62-l circular tanks...

متن کامل

Prothrombin time, activated partial thromboplastin time and other haematological parameters among non-diabetic hypertensive patients.

OBJECTIVES To screen non-diabetic hypertensive Nigerian patients with a view to determining their haematological and coagulation profiles. SUBJECTS AND METHODS Thirty (30) consecutive non-diabetic hypertensive patients, aged 20-60 years and 30 age and sex-matched, apparently healthy subjects, were investigated for some haematological and coagulation parameters, blood pressure, pulse, body wei...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British journal of haematology

دوره 121 3  شماره 

صفحات  -

تاریخ انتشار 2003